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Preparation and in vitro/in vivo characterisation of melt pelletised paracetamol/stearic acid sustained release delivery system. (CROSBI ID 107179)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Grassi, Mario ; Voinovich, Dario ; Grabnar, Iztok ; Franceschinis, Erica ; Perissutti, Beatrice ; Filipović-Grčić, Jelena Preparation and in vitro/in vivo characterisation of melt pelletised paracetamol/stearic acid sustained release delivery system. // Spectroscopy (Ottawa), 18 (2004), 375-386-x

Podaci o odgovornosti

Grassi, Mario ; Voinovich, Dario ; Grabnar, Iztok ; Franceschinis, Erica ; Perissutti, Beatrice ; Filipović-Grčić, Jelena

engleski

Preparation and in vitro/in vivo characterisation of melt pelletised paracetamol/stearic acid sustained release delivery system.

The potential of a sustained release formulation for paracetamol produced by melt pelletisation was investigated. After the production of the pellets, based on the combination of stearic acid as a melting binder and anhydrous lactose as a filler, the 3000-2000 &micro ; m size fraction was selected in the light of the promising in vitro dissolution results for further charac-terisations, including scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), specific surface area and true density determination. Hence the release mechanism was analysed with the help of an appropriate mathematical model. The mathematical model was built on the hypotheses that drug diffusion and solid drug dissolution in the release environment are the key phenomena affecting drug release kinetics. Bioavailability of the developed formulation was evaluated in an in vivo study in eight subjects.

Melt pelletisation; high shear mixer; paracetamol; sustained release; in vitro dissolution; modelling of drug-release

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Podaci o izdanju

18

2004.

375-386-x

objavljeno

0712-4813

Povezanost rada

Farmacija

Indeksiranost