Interactions of acyclic and cyclic bis-phenanthridinium derivatives with ss- and ds- polynucleotides (CROSBI ID 107670)
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Podaci o odgovornosti
Piantanida, Ivo ; Palm, Barbara S. ; Čudić, Predrag ; Žinić, Mladen ; Schneider, Hans-Jorg
engleski
Interactions of acyclic and cyclic bis-phenanthridinium derivatives with ss- and ds- polynucleotides
The acyclic bis-phenanthridinium ligands 1, 2 and the cyclic analogue 3 bind to ss-RNA by bis-intercalation. Due to it's shorter linker 1 exhibits mono-intercalative binding to ds-polynucleotides, while a mixed mode of binding with 2 is shown to strongly dependent on the base composition and tertiary structure of ds-DNA and RNA. The cyclic analogue 3 binds to ds-polynucleotides by non-intercalative mode. Comparing the ss-/ds-polynucleotide selectivity obtained for 3 and previously reported for 3, 8-linked bis-phenanthridinium analogues, it is clear that the more rigid structure and sterically more restricted cleft of the latter could better distinguish ss- from ds-polynucleotide regions.
Bis-phenanthridinium; Intercalation; DNA; RNA.
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