engleski

Influence of the rosemary water extract on the reproduction and postnatal development in rats

Contradictory ethnobotanical data about abortive and teratogenic effects of rosemary (Rosmarinus officinalis L., Lamiaceae) induced us to examine the influence of the water extract from rosemary leaves on the reproduction and postnatal progress of experimental animals. Rosemary leaves were collected in Mediterranean part of Croatia and prepared as 15%(w/V) solution in hot water (RE). Wistar female rats (n=6) were used for testing the influence of RE on the reproduction, growth and progress of the coming generation related to the control group (CG) (n=6). RE was applied daily ad libidum from the beginning of the mating till brood. From 6 female rats in the CG the number of born rats was 59 and in the treated group with RE 38 young. Interestingly, differences in the sex of new born rats were noticed in the tested group with RE (74% of females and 26% of males -ratio 3:1) compared to the CG (48% of females and 52% of males -ratio 1:1). The growth of young rats in the both of groups after the 1st and 2nd month old was also attended where faster postnatal development with RE in grow of young rats during first month was noticed. During the 1 st month the body weigh of young rats from females on RE increased rapidly (mean &plusmn ; SD, male 116.7 &plusmn ; 17.1, female 94.7 &plusmn ; 17.6g, p<0.01) than those born in the CG (male 89.1 &plusmn ; 15.5g, female 74.3 &plusmn ; 11.2g). After the 2nd month the difference in the weight between the RE rats and the CG rats was not more statistically different (RE male 253.1 &plusmn ; 16.9g, RE female 152.4 &plusmn ; 19.6g, respectively CG male 237.8 &plusmn ; 23.8g, CG female 152.6 &plusmn ; 10.2g, p>0.05). RE did not express abortive nor teratogenic effects on rats, but influence on sex of the coming generation has been noticed.

rosemary; water extracts; rat; reproduction

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