engleski

Fibrinolytic activity of earthworms extract (G-90) on lysis of fibrin clots originated from the venous blood of patients with malignant tumors

u-PA is secreted by the most of malignant tumors. The response to those PA syntheses as a tissue protection surrounding cells syntethise the inhibitors of plasminogen activators. Plasminogen activators were found also in earthworm tissue. From the tissue homogenate of earthworm Eisenia foetida the glycolipoproteine mixture named G-90 was isolated. It contain two serin proteases ( P I, P II) with fibrinolytic and anticoagulative activities. The fibrinolytic activity of G-90, P I and P II was tested in “in vitro” euglobulinic test applied to fibrin clot from blood plasma of patients suffered from the malignant tumors. G-90 and above-mentioned proteases applied in this study shorted euglobulinic time proportionally with the concentrations of added substances. The influence of G-90 to fibrinolysis quickness does not depend only on its concentration, but it depends too on hystological type of tissue (organ) where the malignant tumors are located. Enzyme P I and P II do not shows that activity.

fibrinolytic activity ; earthworms extract ; fibrin clot ; malignant tumors

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