engleski

FUNCTIONAL COMMUNICATION OF SERYL-tRNA SYNTHETASE DOMAINS IN SUBSTRATE RECOGNITION

Aminoacyl-tRNAs are key components in protein synthesis. They are formed directly by correct acylation of tRNAs (Crick's hypothesis), or indirectly by tRNA-dependent transformation of misacylated tRNAs. Aminoacyl-tRNA synthetases (AARS) are involved in both types of processes. However, although the fundamental function of tRNA is to act as a specific amino acid carrier, these molecules are also essential for proofreading and editing out non-cognate amino acids by certain AARSs. We have recently elucidated an even more dynamic role of tRNA: seryl-tRNA synthetases (SerRS) recognize serine by a tRNA-dependent mechanism. This pathway, which may serve to increase the accuracy of serylation in vivo, is enabled by the functional communication of SerRS domains in substrate recognition.

tRNA:seryl-tRNA synthetase recognition

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