engleski

Simultaneous Occurence of Glioblastoma Multiforme and Meningeoma. A case Report.

Multiple primary intracranial tumors of different histological type not due to radiotherapy and phacomatosis are rare. A 56-year-old woman presented with a 5-week history of cephalgia. Three months before admission to our hospital in 1999, the patient had experienced a generalized tonic clonic seizure. Upon presentation, neurological examination was unremarkable. A MRI scan revealed a right parieto-occipital tumor of the brain, measuring 4*3cm and intracranial tumor of the left ponto-cerebellar angle, measuring 1, 6*2, 5cm, arising from tentorium. She underwent two craniotomies followed by focal irradiation of the parieto-occipital region. In 2002 a MRI scan demonstrated a recurrence of tumor in the right occipital lobe, measuring 3 cm in diameter. A right parieto-occipital recraniotomy was performed. Neuropathological findings. Histologically, the intraparenchymal tumor was hypercellular with pleomorphic astrocytes. Mitoses, necrosis, and vascular endothelial proliferation confirmed a diagnosis of glioblastoma multiforme. Furthermore, hystological findings of the intracranially located tumor indicated a spindle cell tumor showing a fascicular arrangement with whorling and psamoma bodies. A diagnosis of meningeoma was made. Much speculation remains regarding the origin of multiple tumors of different histological type. Both meningeomas and gliomas are relatively common, therefore their concurrence is probably incidental. On the other hand, meningeoma or glioma can stimulate the adjacent brain parenchyma or arachnoid cells into neoplastic proliferation. However, for tumors in different hemispheres, chance alone is applicable.

glioblastoma multiforme; meningeoma

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