engleski

Evaluation of Bone Mass in Patients with Inflammatory Bowel Disease

A low bone mineral density (BMD) has been reported in patients with inflammatory bowel diseases (IBD). The prevalence of osteoporosis seems to be higher in patients with Crohn's disease (CD) than in those with ulcerative colitis (UC), whereas the prevalence of osteopenia was found to be similar by most studies. Factors associated with bone loss in IBD are the inflammatory activity, corticosteroid use, duration of disease, male sex, low body-mass index, inactivity, hypogonadism, and in CD smoking and surgical reserction. The purpose of the present study was to determine the prevalence of osteopenia and osteoporosis in IBD patients, and to test the influence of clinical variables (age, sex, disease duration, corticosteroid use) on the bone mineral density (BMD). Fifty eight patients with IBD entered the study. BMD was measured by dual-energy x-ray absorptiometry (DEXA). Overall prevalence of osteopenia and osteoporosis was 42% and 30%, respectively. We found no difference between CD and UC patients. There was also no significant difference regarding clinical variables between patients with normal and low BMD. When patients with CD were analized separately, we found statistically significant negative correlation (with correction for age, sex body mass index and corticosteroid use) between BMD and the duration of disease (r=0.58, p=0.002). We conclude that the IBD patients have well defined osteopenia and osteoporosis, the degree of which is not different in CD and UC. Duration of the disease seems to be the only phenomenon related to the low bone mass.

inflammatory bowel disease; bone mass

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