engleski

Risk factors for an unfavorable outcome in juvenile idiopathic arthritis: retrospective study in Croatia.

The aim of our study was to identify risk factors for an unfavorable outcome in children with juvenile idopathic arthritis (JIA). Patients and methods: One hundred ninety-eight children with JIA, first admitted to the Department of Paediatric Rheumatology, University Hospital Zagreb, Croatia, between 1990 and 1995 were examined after 7 to 12 years (median 8.4) of disease duration. Clinical examination, laboratory variables (ESR, platelets, hemoglobin, ANA, HLA-B27 and radiographs of affeceted joints were obtained. Results: At follow up, 119 patients (60, 1%) were in remission, 47 (23, 7%) had developed joint erosions, and 32 (16, 2%) had different functional disabilities, which required orthopedic prostheses or in some cases operation. The remission rate was higher in the patients with persistent oligoarticular than in those with extended oligoarticular and RF positive polyarticular JIA. Conclusion: In our study early risk factors for an unfavorable outcome were young age at onset, female sex, symmetric arthritis (polyarthrtitis), early hip joint involvement, early joint erosions, elevated ESR, positive RF and HLA-B27. The presence of uveitis in oligoarticular onset JIA didn’ t show like unfavorable prognostic factor, like was suggested in some studies

JIA; prognostic; factors

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