Palladium(II) complexes of dialkyl alpha-anilinobenzylphosphonates. Synthesis, characterization, and cytostatic activity (CROSBI ID 77505)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Ćurić, Manda ; Tušek-Božić, Ljerka ; Vikić-Topić, Dražen ; Scarcia, Vito ; Furlani, Ariella ; Balzarini, Jan ; De Clercq, Erick
engleski
Palladium(II) complexes of dialkyl alpha-anilinobenzylphosphonates. Synthesis, characterization, and cytostatic activity
The new palladium(II) halide complexes with diethyl and dibutyl esters of (alpha-anilino-N-benzyl)phosphonic acid and diethyl and dibutyl esters of [alpha- (4-benzeneazoanilino)-N-benzyl]phosphonic acid have been prepared and studied. All organophosphorus ligands form dihalide complexes with monodentate N-bonded ligand through the anilinobenzyl nitrogen in (alpha-anilino-N-benzyl)phosphonate complexes and through the azo nitrogen in [alpha-(4-benzeneazoanilino)-N-benzyl]phosphonate complexes, respectively, without participation of the phosphoryl group. Azobenzene containing ligands by ortho-metallation also form binuclear organo-palladium complexes with the metal-metal chloro bridge. The complexes have been identified and characterized by elemental analysis, infrared and proton NMR, as well as by magnetic and conductometric measurements. All were tested in vitro for their cytostatic activity against KB and L1210 tumor cell lines.
anilinobenzylphosphonates ; palladium(II) complexes ; synthesis ; spectral study ; antitumor activity
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Podaci o izdanju
63 (2)
1996.
125-142
objavljeno
0162-0134
1873-3344
10.1016/0162-0134(95)00199-9