engleski

CORRELATION OF FUNCTIONAL CHANGES IN REGIONAL CEREBRAL BLOOD FLOW MEASURED BY FUNCTIONAL TRANSCRANIAL DOPPLER AND BRAIN SPECT

The purpose of this work was to investigate the validity of functional transcranial Doppler (fTCD) in comparison with technetium-99m-HMPAO single photon emission computed tomography (SPECT) in evaluating regional cerebral blood flow (rCBF) changes during visuospatial activation task. Five healthy righthanded volunteers underwent fTCD blood flow velocity measurement and technetium-99m-HMPAO SPECT rCBF imaging during baseline conditions and during visuospatial activation. Relative changes in cerebral blood flow velocity were measured simultaneously in both middle cerebral arteries (MCA) using averaging algorithm for evoked BFV changes installed in Multi Dop x4 (DWL Elektronische Systeme GmbH). An experienced nuclear medicine physician measured changes in regional cerebral perfusion using regions of interest (ROIs) and visual analysis-based on reading. Functional TCD BFV changes measurement demonstrated slight increase in both MCA (right +25%, left+20%). Subtracting the image in the first scan from that in the second one made a functional SPECT image. ROI analysis identified a variable degree of cortical activation in all patients. Slight perfusion increase was present in the superior parietal cortical areas (right +2.5%, left +1.5%) and parieto-occipital (right +2%, left +0, 4%) regions. Comparable to brain SPECT imaging, fTCD provides high temporal resolution and quantitative information about rCBF, based on relative cerebral BFV changes. Both techniques are useful in detecting alterations in rCBF during mental activity and can be applied to neurophysiologic studies.

Functional transcranial doppler; SPECT

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