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Role of dietary ganglioside GM1 and zeolite clinoptilolite in liver of 1, 2-dimethylhydrazine- treated CF1 mice

The aim of this research was to determine the concentration of gangliosides, sialoglycoproteins and sphingoid bases sphingosine and sphinganine in liver of 1, 2-dimethylhydrazine-treated CF1 mice. CF1 mice were supplied daily with essentially sphingolipid- free diets containing ganglioside GM1 and tribomechanically treated zeolite clinoptilolite TMAZ (diets were supplemented with 0, 025% to 0, 1% GM1 and 2, 5% to 10% zeolite clinoptilolite) or a control, to determine what is the fate of sphingolipids that are consumed in food and how they affect the extraneural organs.

ganglioside GM1 ; sialoglycoproteins ; sphingoid bases ; zeolite clinoptilolite ; CF1 mice ; HPLC

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