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Gluten-Free Diet Has a Beneficial Effect on Chromosome Instability in Lymphocytes of Children With Coeliac Disease (CROSBI ID 110480)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Kolaček, Sanja ; Jadrešin, Oleg ; Petković, Iskra ; Mišak, Zrinjka ; Sonicki, Zdenko ; Booth, Ian Westerby Gluten-Free Diet Has a Beneficial Effect on Chromosome Instability in Lymphocytes of Children With Coeliac Disease // Journal of pediatric gastroenterology and nutrition, 38 (2004), 2; 177-180-x

Podaci o odgovornosti

Kolaček, Sanja ; Jadrešin, Oleg ; Petković, Iskra ; Mišak, Zrinjka ; Sonicki, Zdenko ; Booth, Ian Westerby

engleski

Gluten-Free Diet Has a Beneficial Effect on Chromosome Instability in Lymphocytes of Children With Coeliac Disease

Objectives. Children with coeliac disease (CD) have an increased number of chromosome aberrations in peripheral blood lymphocytes. Whether genetically determined or a secondary phenomenon in CD, chromosome abnormalities may be involved in the predisposition to cancer in CD patients. The aim of the study was to follow a group of children with CD in whom the initial frequency of chromosome aberrations at diagnosis was known and to measure the same variable after a minimum of 2 years on a gluten-free diet. Methods. Chromosome aberrations in peripheral blood lymphocytes were determined in 17 patients with CD, before and after at least 24 months of a gluten free diet (mean, 33 months), and in 15 healthy children. The differences in the frequency of aberrations were analyzed by Mann-Whitney U test and Wilcoxon matched-pairs signed-ranks test. Results. Twelve patients adhered to the diet and had a significantly lower frequency of chromosome aberrations than did 5 patients not following the diet (0.16 v. 1.2% ; p=0.03), wheras at presentation there had been no difference (1.54 v. 1.2% ; p=0.09). The frequency of aberrations at follow-up in patients who were diet adherent patients was significantly lower than at presentation (1.54 v. 0.16% ; p=0.02) and remained unchanged in patients who were not diet adherent (1.2 v. 1.2% ; p=1). After at least 24 months of a gluten free diet, children with CD did not differ from healthy control subjects (0.16 v. 0.27% ; p=0.54), wheras children not following the diet had an increased frequency of aberrations (1.2 v. 0.27% ; p=0.05). Conclusions. The frequency of chromosome aberrations in peripheral blood lymphocytes of patients with CD decreased significantly on a gluten-free diet. We conclude that genomic instability is a secondary phenomenon, possibly caused by chronic intestinal inflammation.

chromosome aberrations; coeliac disease; gluten-free diet

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Podaci o izdanju

38 (2)

2004.

177-180-x

objavljeno

0277-2116

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost