engleski

The role of photodynamic therapy for the treatment of gastrointestinal carcinomas

The discovery that an administered substance could cause photosensitivity is attributed to Oscar Raab, however modern era of photodynamic therapy (PDT) was established by Dr. T. J. Dougherty from Buffalo Memorial Institute (1). He reported that a systemically injected porphyrin (haematoporphyrin), when activated by red light, caused complete eradication of transplanted experimental tumors. He also demonstrated the preferential accumulation of the photosensitizer in malignant tissue . The first clinical application of PDT was in a patient at the Tokyo Medical College with a small upper bronchial squamous cell tumor, treated in 1980 at bronchoscopy with PDT using a laser as the light source. Tumor was completely eradicated . Simultaneously, large obstructing esophageal cancers were similarly treated with PDT with good relief of dysphagia and possible prolongation of survival .

photochemotherapy; photosensitizing agents-therapeutic use; photochemotherapy-instrumentation; Gastrointestinal neoplasms-therapy

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