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Molecules of Escherichia coli MobB assemble into densely packed hollow cylinders in a crystal lattice with 75% solvent content (CROSBI ID 111013)

Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija

Rangarajan, S.E. ; Tocilj, Ante ; Li, Y. ; Iannuzzi, P. ; Matte, A. ; Cygler, M. Molecules of Escherichia coli MobB assemble into densely packed hollow cylinders in a crystal lattice with 75% solvent content // Acta crystallographica. Section D, Biological crystallography, 59 (2003), 12; 2348-2352

Podaci o odgovornosti

Rangarajan, S.E. ; Tocilj, Ante ; Li, Y. ; Iannuzzi, P. ; Matte, A. ; Cygler, M.

engleski

Molecules of Escherichia coli MobB assemble into densely packed hollow cylinders in a crystal lattice with 75% solvent content

The crystal structure of Escherichia coli MobB, an enzyme involved in the final step of molybdenum- cofactor biosynthesis, forms intertwined dimers. Each molecule consists of two segments and requires the second monomer for stable folding. Dimerization buries a quarter of the solvent- accessible area of the monomer. These dimers assemble into a hexagonal lattice with P6(4)22 symmetry and occupy only approximately 25% of the unit-cell volume. The symmetry-related dimers associate tightly into a helical structure with a diameter of 250 A and a pitch of 98 A. Two such helices are intertwined, shifted by 49 A along the sixfold axis. Within the crystal, these helices form thin-walled cylinders with an external diameter of 250 A and an internal diameter of 190 A. Their center is filled with solvent. These cylinders pack closely together, forming a hexagonal lattice with the highest possible packing density. This arrangement of dimers allows extensive intermolecular contacts with 75% solvent content in the crystal.

Escherichia coli MobB crystal lattice

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Podaci o izdanju

59 (12)

2003.

2348-2352

objavljeno

0907-4449

1399-0047

Povezanost rada

Temeljne medicinske znanosti

Indeksiranost