engleski

Respiratory Function and Cigarete Smoking - Path Analysis of Family Data

The path analysis of the respiratory function (as measured by adjusted FEV1) and cigarette smoking habits (measured by smoking index) has been performed on 1198 adult members of nuclear families (age 18 to 85), inhabitants of the islands of Brac, Hvar and Korcula and the Pelješac peninsula, Croatia. The applied Path model encompasses estimation of the following 7 parameters: effects of additive genetic factors on FEV1 in offspring (h) and in parents (hp), effect of shared family environment on smoking behaviour in offspring (c) and in parents (cp), and direct effect of smoking on FEV1 in offspring (d), in fathers (df) and in mothers (dm). The general, most constrained, path model considered (Model 1: h = hp, c = cp, d = dm = df) provided an adequate fit to the data (c2 = 25.68; df = 25; p =0.42). Compared to Model 1, Model 3 (h = hp, c š cp, d = dm = df) was the only one of the group of 6 competing path models to provide a significant improvement in the goodness-of-fit statistics (c2(1) - c2(3) = 25.68 - 21.73 = 3.95; p < 0.05). According to the Model 3, the following values of examined parameters have been obtained: additive genetic effects were estimated at 47%, with no evidence of intergenerational differences in the expression of apparently strong genetic control of pulmonary function (h = hp). Direct effect of an individual's own smoking is responsible for only 1 % variation in FEV1 values in both offspring and parents (d = dp). Family environmental factors that influence an individual's smoking habits (c, cp) were found to be significantly different in two generations explaining 4% of the smoking behaviour in parents and 24% in offspring.

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