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izvor podataka: crosbi

Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator (CROSBI ID 111768)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Starčević, Kristina ; Karminski-Zamola, Grace ; Piantanida, Ivo ; Žinić, Mladen ; Šuman, Lidija ; Kralj, Marijeta Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator // Journal of the American Chemical Society, 127 (2005), 1074-1075-x

Podaci o odgovornosti

Starčević, Kristina ; Karminski-Zamola, Grace ; Piantanida, Ivo ; Žinić, Mladen ; Šuman, Lidija ; Kralj, Marijeta

engleski

Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator

Spectroscopic titrations and thermal denaturation experiments show that "acyclic" analogue 1 does not bind to ds-DNA but under same conditions "cyclic" 2 strongly interacts with ds-DNA and ds-RNA by intercalation into double helix. Besides, 2 is significantly more effective in inhibition of the tumor cell growth in vitro than 1. We have shown that it is possible to efficiently convert "DNA inactive" compound 1 into "DNA active" compound 2 by light irradiation of the aqueous solutions of the former. This strategy offers a new and attractive approach to photodynamic anticancer therapy.

amidines; photoinduced anticancer therapy

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Podaci o izdanju

127

2005.

1074-1075-x

objavljeno

0002-7863

Povezanost rada

Kemija, Temeljne medicinske znanosti