Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator (CROSBI ID 111768)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Starčević, Kristina ; Karminski-Zamola, Grace ; Piantanida, Ivo ; Žinić, Mladen ; Šuman, Lidija ; Kralj, Marijeta
engleski
Photoinduced Switch of a DNA/RNA Inactive Molecule into a Classical Intercalator
Spectroscopic titrations and thermal denaturation experiments show that "acyclic" analogue 1 does not bind to ds-DNA but under same conditions "cyclic" 2 strongly interacts with ds-DNA and ds-RNA by intercalation into double helix. Besides, 2 is significantly more effective in inhibition of the tumor cell growth in vitro than 1. We have shown that it is possible to efficiently convert "DNA inactive" compound 1 into "DNA active" compound 2 by light irradiation of the aqueous solutions of the former. This strategy offers a new and attractive approach to photodynamic anticancer therapy.
amidines; photoinduced anticancer therapy
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
nije evidentirano
Podaci o izdanju
Povezanost rada
Kemija, Temeljne medicinske znanosti