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izvor podataka: crosbi

Effect of a 17-member azalide on tumor cell growth (CROSBI ID 81704)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Grdiša, Mira ; Lopotar, Nevenka ; Pavelić, Krešimir Effect of a 17-member azalide on tumor cell growth // Chemotherapy (Basel), 44 (1998), 331-336-x

Podaci o odgovornosti

Grdiša, Mira ; Lopotar, Nevenka ; Pavelić, Krešimir

engleski

Effect of a 17-member azalide on tumor cell growth

The action of the 17-member azalide 4'-demycarosyl-20-deoxo-20-(di-N-benzylamino)-8a-aza-8a-homotylosin was examined in vitro using five different human cell lines: laryngeal carcinoma (Hep2), pancreatic carcinoma (MiaPaCa2), breast carcinoma (MCF7), neuroblastoma, and normal diploid fibroblast (Hef522). After exposure, the cell growth was arrested, and morphological changes occurred in a dose-dependent manner. At a concentration of 10(-4) M the azalide completely inhibited the growth of all cell lines examined and induced morphological changes such as cell shrinkage, chromatin condensation, and DNA fragmentation. These features point to apoptosis.

azalide; macrolide; antitumor activity; apoptosis

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Podaci o izdanju

44

1998.

331-336-x

objavljeno

0009-3157

Povezanost rada

Javno zdravstvo i zdravstvena zaštita

Indeksiranost