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izvor podataka: crosbi

Changes of lymphoid homeostasis and inhibition of liver regeneration provoked by sandostatin in mice (CROSBI ID 111966)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Ćuk, Mira ; Radošević-Stašić, Biserka ; Milin, Čedomila ; Mrakovčić-Šutić, Ines ; Barac-Latas, Vesna ; Petković, Marija ; Muhvić, Damir ; Verbanac, Donatella ; Rukavina, Daniel Changes of lymphoid homeostasis and inhibition of liver regeneration provoked by sandostatin in mice // Periodicum biologorum, 92 (1990), 1; 38-39-x

Podaci o odgovornosti

Ćuk, Mira ; Radošević-Stašić, Biserka ; Milin, Čedomila ; Mrakovčić-Šutić, Ines ; Barac-Latas, Vesna ; Petković, Marija ; Muhvić, Damir ; Verbanac, Donatella ; Rukavina, Daniel

engleski

Changes of lymphoid homeostasis and inhibition of liver regeneration provoked by sandostatin in mice

Compensatory liver growth (CLG) may be significatly inhibited by treatment with Sandostatin (SMS), but the data show that some inhibitory effects might also be provoked by the concommitant stress related to the procedure of repeated injecting. Some inhibiting effects on hepatic DNA was obtained by SMS also in sham hepatectomized (Hx) mice, but similar changes were not seen in the liver of unoperated animals indicating the greater modulatory action of SMS on liver cells activated by partial hepatectomy (pHx) or operative stress. Analysis of the lymphohematopoetic status of the same animals however, has shown that SMS particularly affects the lymphatic organs of partially Hx mice. In these animals SMS potentiated the depletion of bone marrow and thymus and produced a significant hypoplasia of spleen. These results suggest growth and immunoregulatory properties of SMS especially after disturbance of morphostasis by pHx.

lymphoid homeostasis; liver regeneration; sandostatin

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Podaci o izdanju

92 (1)

1990.

38-39-x

objavljeno

0031-5362

Povezanost rada

nije evidentirano

Indeksiranost