engleski

Synthesis and characterization of thiomers of polyaspartamide type

Synthesis of poly[alfa, beta-(N-2-hydroxyethyl-dl-aspartamide)-thioglycolic acid (PHEA-TGA)conjugate as a new polyaspartamide thiomer is described. The parent polymer PHEA is chemically modified by introducing sulphydryl-bearing compound thioglycolic acid. By varying the reaction conditions several batches of PHEA-TGA conjugates were prepared and analyzed. Tensile studies revealed that totalwork of adhesion of PHEA-TGA increased more than twice compared to the unmodified polymer. Microparticles prepared from the thiolated polymer preserved its bioadhesive properties.

thiomer; polyaspartamide; thioglycolic; mucoadhesion; micoparticles

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