Compartmentalization of growth factor receptor signalling (CROSBI ID 112771)
Prilog u časopisu | pregledni rad (znanstveni) | međunarodna recenzija
Podaci o odgovornosti
Hoeller, Daniela ; Volarević, Siniša ; Đikić, Ivan
engleski
Compartmentalization of growth factor receptor signalling
Spatial and temporal separation of signal transduction pathways often determines the specificity in cellular responses. Recent advances have improved our understanding of how growth factor signalling is influenced by the formation of molecular complexes (signalosomes) in distinct cellular compartments. There has also been new insight into the mechanisms that determine the signalling competence of these complexes and their role in receptor endocytosis, retrograde trafficking in neurons and restricted protein biosynthesis, and many examples have been found where signalosome deregulation leads to disease.
Signalling; compartmentalization; growth factor receptors; ribosomes; signalling and selective translation; diseases
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