Preparation of enantiomers of quinuclidin-3-ol derivatives and their interactions with human cholinesterases (CROSBI ID 505775)
Prilog sa skupa u časopisu | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Simeon-Rudolf, Vera ; Tomić, Srđanka ; Anita, Bosak ; Primožič, Ines ; Oršulić, Mislav
engleski
Preparation of enantiomers of quinuclidin-3-ol derivatives and their interactions with human cholinesterases
The stereoselectivity of acetylcholinesterase (EC 3.1.1.7) and butyrylcholinesterase (EC 3.1.1.8) was studied in the interaction with enantiomers of quinuclidin-3-yl acetates as substrates as well as in the reversible inhibition of the enzymes by enantiomers of quinuclidin-3-ol derivatives. For that purpose (R)- and (S)-alcohols and their acetates as well as their quaternary N-methyl and N-benzyl derivatives were prepared and characterized.
acetylcholinesterase ; butyrylcholinesterase ; chiral substrates and inhibitors ; quinuclidine-3-ol derivatives
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Podaci o prilogu
420-421.
2005.
nije evidentirano
objavljeno
10.1016/j.cbi.2005.10.086
Podaci o matičnoj publikaciji
Chemico-biological interactions
Bond, James A.
Elsevier
0009-2797
Podaci o skupu
Nepoznat skup
poster
29.02.1904-29.02.2096
