engleski

Soluble adhesive molecules in hypertension are reflective of profound pathogenesis disturbance

The structure of the selected participants, in this study, beeing predominantly older, postmenopausal and overweight women, reflects the real epidemiological situation, provading possible insight into the biological complexity of the investigated metabolic disturbances. According to the epidemiological data, in general population, over age of 50, the females have higher BMI, and are more frequently hypertensive, than the males. These changes in the women risk-status overlaps with the onset of the menopause, with coincidence of the menopause, age, obesity and hypertension (47). In general, soluble adhesion molecules might not be raised in hypertensive patients, compared to the nonhypertensive controls. Even among the participants of the same study group, there may be the substantial heterogeneity, concerning the high variability of some traits, such as triglycerides, or CRP, which may affect the results. The analysis of correlations showed the association of the sE-selectin levels with the parameters representing various features of the insulin resistance syndrome. Parameters selected to be associated with sP-selectin levels, imply disturbed hemorheology. All these observations lead to the conclusion that raised levels of the soluble adhesion molecules, in hypertensive patients, may not be merely the consequence of high blood pressure, but rather reflect common underlying pathogenetic disturbances. Each of the molecule measured, may indicate a particular aspect of the same disorder, or, they may be the components of the overlapping syndromes, by sharing some common parameters.

E-selectin; P-selectin; hypertension; endothelial cells

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