engleski

Pentagastrin Cytoprotection in Ethanol-Induced Gastric Mucosal Lesion in Rats

To establish pentagastrin cytoprotection, the effectiveness of various doses pangastrin on ethanol induced gastric mucosal lesion was investigated in Wistar rats. Significant protection was obtained only after parenteral pretreatment with the exception of the lowest dose (1 microgram/kg b.w.). Pengastrin cytoprotection is not mediated either by dopamine, muscarine or gastrin/CCK receptor or by prostaglandin synthesis. However, the protective effect of pentagastrin is abolished by prior vagotomy, althouth this procedure alone or sham operation is ineffective to influencing control-ethanol lesions. In secretory studies pentagastrin increased both the volume of gastric juice and total acid output. Unlike cytoprotection, these were reversed by vagotomy, but also with atropine and problumide, whereas domperidone and indomethacin wer ineffective.

pentagastrin; cytoprotection; stomach; rat

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