engleski

Recognition of homo-polynucleotides containing adenine by phenanthridinium bis-uracil conjugate in aqueous media.

Among novel bis-nucleobase - phenanthridinium conjugates bis-uracil analogue 2 stabilized significantly more effective poly dA - poly dT and poly AH+ - poly AH+ than adenine analogue 3 and referent compound 1. For the alternating poly dAdT - poly dAdT however, the binding preference is lost pointing to the importance of specific interactions of uracils of 2 with homopolynucleotides containing consecutive adenines.

DNA; intercalator-nucleobase conjugate; recognition of poly A

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