engleski

Antitumor activity of bee venom

Background and Purpose: If hers been reported that bee venom exhibits antitumor activity in vitro. The aim of this study was to investigate potential antimetastatic and in vivo antitumor activity of the bee venom. Materials and Methods: Bee venom from "Medex" (Ljubljana, Slovenia) was collected utilizing the electric shock method. Its antitumor activity was examined on a transplantable spontaneous mammary carcinoma (MCa) in CBA mice in vivo, and HeLa and V79 cell lines in vitro. Results: Bee venom showed an antitumor effect depending on concentration and on route of injection in vivo and inhibited cell growth and clonogenicity in vitro. The strongest inhibitory effect in vitro was on the V79 cell line Conclusions: An antitumor effect of the bee venom was established in vivo and in vitro. Apoptosis, necrosis and lysis of the tumor cells were found to be the possible mechanisms by which bee venom inhibited tumor growth.

Melanotropin receptor function; Melanoma cell-line; Adenylate-cyclase; Beta-melanotropin; Phospholipase-A; Flow-cytometry; Calmodulin; Melittin; Growth; Inhibition

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