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Soluble transferrin receptor and transferrin receptor-ferritin index in iron deficiency anemia and anemia in rheumatoid arthritis

The aim of the study was to evaluate the clinical efficiency of soluble transferrin receptor and transferrin receptor-ferritin index in the diagnosis of iron deficiency anemia and differential diagnosis of iron deficiency anemia and anemia in rheumatoid arthritis. The study included 96 patients with anemia and 61 healthy volunteers as a control group. In healthy subjects there were no significant sex and age differences in tested parameters. Study results showed these parameters to be reliable in the diagnosis of iron deficiency anemia as well as in differential diagnosis of iron deficiency anemia and anemia of chronic disease. The results indicated that sTfR/logF could be used to help differentiate coexisting iron deficiency in patients with anemia of chronic disease. Receiver operating characteristic analysis showed a higher discriminating power of transferrin receptor-ferritin index versus soluble transferrin receptor in the diagnosis of iron deficiency anemia as well as in differential diagnosis between iron deficiency anemia and anemia of chronic disease. In patients with anemia in rheumatoid arthritis, the tested parameters showed no significant differences according to C-reactive protein concentration. These results suggested the tested parameters not to be affected by acute or chronic inflammatory disease.

anemia in rheumatoid arthritis; iron deficiency anemia; soluble transferrin receptor; transferrin receptor-ferritin index

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