engleski

Liver Fatty Acid and Element Changes After Partial Hepatectomy in Mice Fed Olive-Oil and Corn-Oil Enriched Diet

The purpose of this study was to explore the effect of dietary fats on hepatic fatty acid profile of mice liver after partial hepatectomy, and observe a correlation with changes in element content. Male Balb/C mice were divided into three groups: control animals fed standard diet (FSD), FOO group fed diet enriched with 5% of olive oil and FCO group fed diet enriched with 5% of corn oil. Hepatic fatty acid and element content were analysed within each group in intact animals, and on days 1, 2, and 7 after partial hepatectomy. During the regenerative process proportions of 18:1n-9 and 18:3n-6 highly increased in FSD diet, correlating with Zn level. On the other hand, 20:4n-6 and 22:6n-3 decreased on day 1 and 2. Consequently, a significant increase in the n-6:n-3 ratio was found in these animals. In FOO diet decreased PUFA/MUFA ratio was related to a significant decrease in PUFA content, mainly due to decreased 20:3n-6 and 20:4n-6. Proportion of 18:1n-9 was highly increased when compared with other diets, and remained high during the regeneration. Furthermore, n-6:n-3 ratio was increased on day 2 and 7. Zn increased on day 1 and 2, and Fe on day 2. Feeding with corn oil generally induced increase in PUFA n-6 series, compared with other diets. PUFA n-3 series decreased and 18:1n-9 increased on day 1, compared to intact animals. Consequently, n-6:n-3 ratio was elevated during the regeneration. Zn increased on day 1 and 2, while Fe remained unchanged until day 7 when decreased. Decreased 20:4n-6 on day 1 and 2, as well as Cu on day 7, and increased Zn first two days were in common to all three diets. These findings suggest that some significant signals transmitted during the regenerative process have induced alterations in the fatty acid composition and changes in the liver element content, which can be modified by the diet.

zinc; iron; copper; magnesium; olive oil; corn oil; liver regeneration

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