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Immunosuppressive and antiproliferative effects of somatostatin analog 201-995

The effects of long acting somatostatin analog SMS 201-995 were examined in vivo on: Lymphoid morphostasis and functional reactivity of cells obtained from SMS treated donors, on humoral, and cellular type of immunity, and in vitro on blastic transformation of lymphocytes stimulated by activators of different transmembrane pathways (CD2 by PHA and CD3/TRC by anti-CD3 monoclonal antibody and by allogeneic cells) and on growth and secretory activity of several hybridoma cell lines. The data have shown that SMS in vivo decreases the proportion of CD4, CD5 and Ig+ cells in spleen. The reactivity of these cells to Con A was suppressed, but their spontaneous blastic transformation was increased. SMS suppressed also the PFC generation and proliferation of cells in popliteal lymph nodes during the local host versus graft reaction. The data obtained in vitro revealed that SMS may inhibit only CD2-induced blastogenesis (in early and late interval after the use of PHA). SMS inhibited also the spontaneous growth and/or secretion of antibodies in some hybridoma cell lines.

SMS 201-995 ; immunosuppression ; CD2 and CD3/TRC-dependent blastogenesis ; growth of hybridoma cell lines

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