engleski

Clinical relevance of the serum dipeptidyl peptidase IV (DPP IV/CD26) activity in adult patients with Crohn's disease and ulcerative colitis

The dipeptidyl peptidase IV (DPP IV/CD26), a serine-type protease, is a membrane anchored enzyme widely expressed in many cell types. DPP IV is also present in a soluble form in the serum. The aim of this study was to evaluate the clinical relevance of the changes in serum DPP IV activity in adult patients with inflammatory bowel diseases (Crohn&#8217; s disease, CD and Ulcerative colitis, UC). The study was performed on 59 patients, 35 with CD (age 42, 60 &#177; ; ; ; ; ; ; ; 15, 89 ; 17 males, 18 females), and 24 with UC (age 46, 62 &#177; ; ; ; ; ; ; ; 16, 97 ; 13 males, 11 females). The diagnosis of CD or UC were established on the basis of clinical history, laboratory, endoscopic and histological data. The control group included 68 healthy donors (age 41, 01 &#177; ; ; ; ; ; ; ; 11, 85 ; 33 males, 35 females). The CD activity was evaluated using the Crohn´s Disease Activity Index (CDAI) while the UC activity was evaluated by the Truelove - Witts (TW) classification. Both serum DPP IV activities in patients with active CD (35, 31 &#177; ; ; ; ; ; ; ; 1, 55 U/L) and UC (33, 93 &#177; ; ; ; ; ; ; ; 2, 13 U/L) were statistically significantly decreased compared with healthy controls (48, 37 &#177; ; ; ; ; ; ; ; 1, 10 U/L), (p<0, 001). The levels of DPP IV activity in CD and UC patients were inversely correlated with the CDAI and TW score, respectively. As it has been shown that there is no statistically significant difference in the serum DPP IV activity between patients with CD and UC, it can be concluded that the DPP IV could not be a good marker for the differential diagnosis.

serum DPP IV activity; CD26; Crohn's disease; ulcerative colitis

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