engleski

Oxidative stress in dairy cows - serum paraoxonase activity related to hepatomegaly

The association of serum paraoxonase (PON) activity and hepatomegaly in dairy cows as well as the relation between PON activity and HDL-cholesterol concentration were studied, considering the role of oxidative stress in reproductive and metabolic disorders in dairy caws. A significantly lower PON activity (p<0.01) was found in cows with hepatomegaly compared to clinical healthy cows. The serum glucose, triglyceride and cholesterol concentrations were also markedly reduced in cows with hepatomegaly (p<0.001, p<0.001 and p<0.05, respectively), whereas the serum HDL-cholesterol concentration showed no significant change. Paraoxonase/HDL-cholesterol ratio in hepatomegaly was significantly lower (p<0.05) as well. As a part of antioxidative defence against lipid peroxidation, a lower PON activity contributes to the increased risk of oxidative stress in cows with hepatomeg

paraoxonase; HDL-cholesterol; oxidative stress; dairy cows; fatty liver

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