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Recovery of immune system in diabetic mice after treatment with insulin (CROSBI ID 113963)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Pavelić, Krešimir ; Slijepčević, Milivoj ; Pavelić, Jasminka Recovery of immune system in diabetic mice after treatment with insulin // Hormone and Metabolic Research, 10 (1978), 5; 381-386. doi: 10.1055/s-0028-1093396

Podaci o odgovornosti

Pavelić, Krešimir ; Slijepčević, Milivoj ; Pavelić, Jasminka

engleski

Recovery of immune system in diabetic mice after treatment with insulin

In mice with alloxan-induced diabetes, humoral and cellular immunological reactivity were weak. The number of leucocytes, and especially lymphocytes, was reduced, and the weight and cellularity of lymphatic organs were lower than in normal mice. Treatment of diabetic mice with insulin reversed morphological and functional deficiency of the immunological system. Observed depression of immunological functions was attributed to impaired transport of glucose into immunocompetent cells, rather than to toxic effects of alloxan.

immune system ; diabetic mice

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Podaci o izdanju

10 (5)

1978.

381-386

objavljeno

0018-5043

10.1055/s-0028-1093396

Povezanost rada

Temeljne medicinske znanosti

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