engleski

Statins in the prevention of cerebrovascular disease

A relationship exists between cholesterol levels and occurence of stroke, and elevated cholesterol levels should be considered a risk factor for stroke in addition to other well known risk factors. Reduction in the risk of stroke ranges from 19 percent (LIPID study), through 28 percent and 29 percent (4S study and Herbert literature search, respectively) to 31 percent (CARE study). Ischemic stroke is primarily caused by thrombus formation from the rupture of unstable plaques in the intimal lining of blood vessels. Statins could stabilize the plaque, thus making it less likely to rupture. All primary and secondary intervention trials have shown that the significant reductions in low-density lipoprotein (LDL) cholesterol achieved with statins result in significant reductions in the morbidity and mortality associated with coronary artery disease as well as reductions in the incidence of stroke and total mortality. Experimental studies have also shown statin-induced improvements in endothelial function, decreased platelet thrombus formation, and improvements in fibrinolytic activity.

statins; cerebrovascular disease; prevention

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