Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Palindrome content of the yeast Saccharomyces cerevisiae genome (CROSBI ID 114012)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Lisnić, Berislav ; Svetec, Ivan-Krešimir ; Šarić, Hrvoje ; Nikolić, Ivan ; Zgaga, Zoran Palindrome content of the yeast Saccharomyces cerevisiae genome // Current genetics, 47 (2005), 5; 289-297-x

Podaci o odgovornosti

Lisnić, Berislav ; Svetec, Ivan-Krešimir ; Šarić, Hrvoje ; Nikolić, Ivan ; Zgaga, Zoran

engleski

Palindrome content of the yeast Saccharomyces cerevisiae genome

Palindromic sequences are important DNA motifs involved in the regulation of different cellular processes but are also a potential source of genetic instability. In order to initiate a systematic study of palindromes at the whole genome level we developed a computer program that may identify, locate and count palindromes in a given sequence in a strictly defined way. All palindromes can be analyzed and sorted according to their size, frequency, GC content or alphabetically. This program was then used to prepare a catalog of all palindromic sequences present in the Saccharomyces cerevisiae genome, but also in randomly generated equivalents of the yeast genome. For each palindrome size the observed palindrome frequencies were significantly different from those found in the randomly generated genomes. However, while the short palindromes (up to 12 bp) were less frequent, the longer palindromes were more frequent, AT- rich and preferentially located in the intergenic regions. The 44 bp palindrome found between the genes CDC53 and LYS21 on chromosome IV was the longest palindrome identified and contained only two C-G base pairs. Avoidance of coding regions was also observed for 4 - 10 bp palindromes, but was less pronounced. Dinucleotide analysis indicated a strong bias against palindromic dinucleotides that could explain the observed short palindrome avoidance. We discuss the possible mechanisms that may influence the evolutionary dynamics of palindromic sequences in the yeast genome.

palindrome; inverted repeat; dinucleotide; Saccharomyces cerevisiae; sequence analysis

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o izdanju

47 (5)

2005.

289-297-x

objavljeno

0172-8083

Povezanost rada

Biotehnologija

Indeksiranost