Growth factors in human tumors (CROSBI ID 114014)
Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija
Podaci o odgovornosti
Krušlin, Božo ; Levanat, Sonja ; Baltić, Vladimir ; Milković, Dubravka ; Pavelić, Jasminka ; Spaventi, Radan ; Spaventi, Šime ; Pavelić, Krešimir
engleski
Growth factors in human tumors
Various human tumor tissues contain different growth factors. In some cases progression of tumors is paralleled by elevated levels of these substances in blood or in tumor tissue. There is evidence that these growth promoting peptides might stimulate tumor growth. The growth of most tumors was associated with insulin-like substances (MW 45 000). We isolated and purified a substance immunologically cross-reactive with insulin (SICRI) from human melanoma. We found the molecular weight of affinity purified SICRI to be approximately 120 000. Our in vitro experiments with human renal carcinoma cells and growth factors suggest an important role of these molecules in tumor progression.
growth factors ; human tumors ; peptides ; tumor progression
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Podaci o izdanju
189 (2)
1989.
91-99
objavljeno
0300-9130
1433-8580
10.1007/BF01851259
Povezanost rada
Temeljne medicinske znanosti