Nerve growth factor (NGF) induced differentiation of human neuroblastoma cells (CROSBI ID 114210)
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Podaci o odgovornosti
Pavelić, Krešimir ; Spaventi, Šime
engleski
Nerve growth factor (NGF) induced differentiation of human neuroblastoma cells
Nerve growth factor (NGF) induced differentiation of human neuroblastoma cells. The differentiated cells had a relatively high activity of adenylate cyclase and cyclic AMP phosphodiesterase, and a high intracellular level of cyclic AMP. These cells synthesized a higher amount of met5-oenkephalin than undifferentiated cells. Undifferentiated cells bound less met5-enkephalin than differentiated cells. The maximum number of [3H]met5-enkephalin receptor sites per mg of membrane protein increased more in differentiated cells. Previous observations taken together with our results suggests that increased intracellular levels of cyclic AMP after treatment with NGF induced differentiation of human neuroblastoma cells. Reversal of undifferentiated tumor cells into the differentiated changes the capacity of synthesis of met5-enkephalin and its interaction with receptors.
nerve growth factor (NGF) ; diffenetiation ; human neurofibrosarcoma cells
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Podaci o izdanju
19 (12)
1987.
1237-1240
objavljeno
0020-711X
10.1016/0020-711X(87)90110-8
Povezanost rada
Temeljne medicinske znanosti