engleski

Chemotherapy and immunotherapy of diabetic and non-diabetic mice bearing fibrosarcoma

Cells of methylcholanthrene-induced fibrosarcoma were transplanted into normal mice, diabetic mice and into diabetic mice treated with insulin. The tumour growth rate and the effects of the therapy with drugs (cyclophosphamide, methotrexate) and Corynebacterium parvum were followed. Tumours grew more slowly in diabetic than in non-diabetic or insulin-treated diabetic hosts. Chemotherapy prolonged the survival equally in all experimental groups of mice, but immunotherapy was effective only in non-diabetic and insulin-treated diabetic fibrosarcoma-bearers. If the malignant cells from the diabetic donor were transplanted into secondary diabetic recipient, the tumour growth rate was again the same as in nondiabetic hosts. Chemotherapy was even more effective in these tumour-bearers, but the immunotherapy did not show any antimalignant effect. This discrepancy was attributed to different modes of action of cytostatic drugs and of bacterial immunostimulant.

chemotherapy and immunotherapy ; diabetic ; non-diabetic mice ; fibrosarcoma

nije evidentirano