Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates (CROSBI ID 114459)
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Zovko, Marijana ; Barbarić, Monika ; Zorc, Branka ; Hafner, Anita ; Filipović-Grčić, Jelena
engleski
Synthesis of fenoprofen and gemfibrozil styrene-maleic acid copolymer conjugates
Two types of polymer-drug conjugates were synthesized starting from styrene-maleic acid anhydride copolymer (SMA). Fenoprofen and gemfibrozil were chosen as model drugs because of their short plasma half lives. Both drugs were first converted to their 2-aminoethylamides, which possess free amino groups capable of reacting with SMA anhydride rings. By modifying the degree and type of substitution, lipophilic and hydrophilic conjugates were obtained. Drug loading in the conjugates was between 17 and 47%.
fenoprofen; gemfibrozil; polymer drug conjugate; styrene-maleic acid copolymer
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