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izvor podataka: crosbi

Fibre type-specific and nerve-dependent regulation of myosin light chain 1 slow promoter in regenerating muscle (CROSBI ID 114893)

Prilog u časopisu | izvorni znanstveni rad | međunarodna recenzija

Jerković, Romana ; Vitadello, M. ; Kelly, R. ; Buckingham, M. ; Schiaffino, S. Fibre type-specific and nerve-dependent regulation of myosin light chain 1 slow promoter in regenerating muscle // Journal of muscle research and cell motility, 18 (1997), 3; 369-373-x

Podaci o odgovornosti

Jerković, Romana ; Vitadello, M. ; Kelly, R. ; Buckingham, M. ; Schiaffino, S.

engleski

Fibre type-specific and nerve-dependent regulation of myosin light chain 1 slow promoter in regenerating muscle

The regulation of a slow muscle gene, the myosin light chain 1 slow/ventricular gene, has been studied by in vivo transfection into regenerating rat skeletal muscle. Constructs containing portions of the myosin light chain 1 slow/ventricular promoter linked to reporter genes were injected into fast and slow muscles 3 days after muscle injury by bupivacaine injection, and reporter gene activity was analysed after 10 days. We report that a sequence in the 5' flanking region of the myosin light chain 1 slow/ventricular gene is able to direct slow muscle-specific regulation of reporter genes, and that the expression of the transgene, like that of the corresponding endogenous gene, is dependent on intact nerve. This study validates the use of regenerating muscle as a model for studying muscle gene regulation and is the first demonstration of a myosin gene promoter regulated by nerve activity.

skeletal-muscle; transgenic mice; gene-transfer; heavy-chain; expression; cat

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Podaci o izdanju

18 (3)

1997.

369-373-x

objavljeno

0142-4319

Povezanost rada

nije evidentirano

Indeksiranost