engleski

Assessment of haemodialysis adequacy by ionic dialysance: comparison to standard method of urea removal

Background. The haemodialysis adequacy is one of the most important issues influencing the survival of patients on maintenance haemodialysis (HD). Assessment of measuring the delivered dialysis dose using Kt/V index requires multiple blood sampling. New methods for assessment of dialysis dose based on ionic dialysance (ID) have been suggested. Online conductivity monitoring (using sodium flux as a surrogate for urea) allows the repeated non-invasive measurement of Kt/V on each HD treatment. In this study we have compared this method with the standard method of estimating Kt/V. Methods. We studied 24 established HD patients over 4 weeks time period. Patients were dialysed using Fresenius 4008S dialysis monitors, equipped with modules to measure ID. Data were manually collected and analysed using the appropriate statistical software. Urea removal (UR) was measured once a week by a two-pool calculation, estimating an eKt/V. Results. The Kt/V measured by ID highly correlated with the one derived from the measurement of the UR (r=0.8959, p<0.0001). The ID underestimated UR by the mean of 6%. The ID varied greatly within individual patients with a median of 1.29 +/- 0.22. If the eKt/V&#8805; 1.2 is considered adequate, 33% of the patients would have been inadequately dialysed. The mean HD duration to achieve an adequate dialysis was 4 hours and 47 minutes with high inter-patient variability. Conclusion. The ID seems to be an easily obtained measure of the delivered dialysis dose, well correlating with standard UR method. Substantial individual variations imply that repeated measures (ideally for all treatments) are necessary to obtain a real answer of the mean treatment dose being delivered to the patients.

adequacy of dialysis; ionic dialysance; Kt/V; Urea removal

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