Conversion of thyroxine to triiodothyronine and reverse triiodothyronine in human placenta and fetal membranes (CROSBI ID 115372)
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Podaci o odgovornosti
Banovac, Krešimir ; Bzik, Ljubica ; Tišlarić, Dubravka ; Sekso, Mladen
engleski
Conversion of thyroxine to triiodothyronine and reverse triiodothyronine in human placenta and fetal membranes
Conversion of thyroxine (T4) to 3, 5, 3'- triiodothyronine (T3) and reverse 3, 3', 5'- triiodothyronine (rT3) was measured in vitro in human placenta and fetal membranes. T4 (5 mcg/ml) was incubated in 0.15 mol/l phosphate buffer with tissue homogenates for 2h at 37 C, and T3 and rT3 generated were determined in ethanol extract using RIA methods. The placenta and chorion homogenates converted more T4 to T3 than to rT3 ; the placenta was more active than the chorion. In both tissues the highest converting activity was found in microsomal fractions.
Thyroxine conversion ; Human placenta ; Chorion
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Podaci o izdanju
Povezanost rada
Temeljne medicinske znanosti