engleski

Frequency of sister chromatid exchange in cigarette industry workers

Occupational exposure of cigarette industry workers includes exposure to numerous volatile components that can cause adverse health effects such as allergies and respiratory disorders, as well as malignant diseases. To evaluate genotoxic effect of tobacco dust the frequency of sister chromatid exchanges (SCE) was analyzed in peripheral blood lymphocytes of cigarette industry workers. The number of high frequency cells (HFC) was also determined. The study comprised 30 tobacco industry workers of both sexes who were, in addition to tobacco dust, exposed to a source of strontium 90, used to control the density of tobacco filler in cigarettes, and 30 control subjects matched for sex, age and smoking habit. The statistical analysis was performed using the ANOVA. The results showed significant difference in both SCE frequency and the number of HFC between the exposed and control group. Exposure duration did not influence the SCE frequency, nor did sex and age. On the other hand, smoking proved to influence SCE frequencies in both groups. Smokers from the exposed group showed a significant increase in SCE frequency in respect to smokers in the control group.

occupational exposure; sister chromatid exchange; cigarette industry workers

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