engleski

Ochratoxin A concentration and sphinganine and sphingosine ratio in urine of persons from region with endemic nephropathy

Endemic nephropathy (EN) is human fatal renal disease of unknown origin that occurs in geographically limited area of Croatia and some other countries. The most plausible theory of the aetiology of EN links it with the exposure to nephrotoxic mycotoxins through ingestion of contaminated food. In this study the concentration of mycotoxin ochratoxin A (OTA) and sphingosine/sphinganine (Sa/So) ratio, the biomarker of fumonisins exposure, were checked in human urine collected in endemic village (Kaniža) in Croatia and in a control village. The mean OTA concentration in urine of the group of subjects at risk (relatives of patients with EN, N=31), group of suspected (with some signs of EN, N=19), and in healthy persons from EN village, (N=21) were 4.3, 1.8, and 0.9 ng/ml, respectively. The mean concentration in control group (N=33) was 2.1 ng OTA/ml, and was not statistically different to other groups. The mean Sa/So ratio in urine of subjects at risk, healthy subjects and in suspected was 0.82, 0.80, 0.51, respectively. Although this ratio was the lowest in control group, (0.16) there was no statistical difference when compared to other groups. There was no correlation of OTA concentration and Sa/So ratio in urine.

endemic nephropathy; urine; mycotoxins; ochratoxin A; fumonisins

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