ELECTROCHEMICAL STUDIES OF BIOLOGICALLY ACTIVE AZO COMPOUNDS (CROSBI ID 508866)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | domaća recenzija
Podaci o odgovornosti
Nigović, Biljana
engleski
ELECTROCHEMICAL STUDIES OF BIOLOGICALLY ACTIVE AZO COMPOUNDS
Electrochemistry is fast growing area with a number of possible applications in the pharmaceutical field. It can be used at the early stage of drug research for electroorganic synthesis of pharmacologically interesting molecules and screening the activity of newly synthesized molecules. A number of correlations between redox potential and activity have been noted. Electron transfer reactions play important role in understanding of the mechanism of action of various drugs and can serve as a useful tool in the design of more active and safer pharmaceuticals. In drug research, electrochemical techniques have application to drug-protein and drug-DNA binding studies giving results useful in drug bioavailability and toxicity tests. Electrochemical methods cover a large domain of investigation in drug analysis ranging from the assay of drugs in bulk form, pharmaceutical formulations and drug therapy monitoring in biological fluids. The advance in microelectrodes has prompted in vivo investigations of processes occurring within biological system. Azo compounds, salicylazosulfapyridine and 3, 3’ -azobis-(6-hydroxybenzoic acid) disodium salt, are used in therapy for the treatment of chronic inflammatory bowel diseases. The therapeutic effect has been attributed to the action of 5-aminosalycilic acid which is produced in the colon by bacterial reduction of the azo bridge. Various pharmaceutical approaches for the delivery of the pharmacologically active moiety to the colon have been reported. Among the different colon-targeted prodrugs, 2-hydroxy-5-[(4-sulfophenyl)azo]benzoic acid, has been designed. Since the bacterial cleavage of the azo compounds is reductive process, the knowledge of the mechanism of their electrode reaction could provide a useful clue in elucidation of the reduction mechanism in biological system. The electrochemical behaviour of differentially substituted azosalicylic acids has been studied at hanging mercury drop electrode by cyclic voltammetry as a model of the metabolic reduction of these substances. The reduction of biologically active azosalicylic acids yield either the corresponding amines, as a result of the cleavage of azo bonds, or a hydrazo intermediate, depending on the pH of the medium and the type of substituent in aromatic ring.
reduction mechanism; cyclic voltammetry; azosalicylic acid; olsalazine
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Podaci o prilogu
35-35.-x.
2005.
objavljeno
Podaci o matičnoj publikaciji
Knjiga sažetaka = Book of abstracts / Treći hrvatski kongres farmacije
Zorc, Branka
Zagreb: Farmaceutsko-biokemijski fakultet Sveučilišta u Zagrebu
Podaci o skupu
Treći hrvatski kongres farmacije
predavanje
27.04.2005-01.05.2005
Cavtat, Hrvatska