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Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6. (CROSBI ID 509013)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Volarević, Siniša Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6.. 2001

Podaci o odgovornosti

Volarević, Siniša

engleski

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6.

Because ribosome biogenesis plays an essential role in cell proliferation, control mechanisms may have evolved to recognize lesions in this critical anabolic process. To test this possibility, we conditionally deleted the gene encoding 40S ribosomal protein S6 in the liver of adult mice. Unexpectedly, livers from fasted animals deficient in S6 grew in response to nutrients even though biogenesis of 40S ribosomes was abolished. However, liver cells failed to proliferate or induce cyclin E expression after partial hepatectomy, despite formation of active cyclin D-CDK4 complexes. These results imply that abrogation of 40S ribosome biogenesis may induce a checkpoint control that prevents cell cycle progression.

cell proliferation; cell growth; ribosomal protein S6

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

2001.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Podaci o skupu

EMBO Lecture Course: Cellular signaling in development and disease

pozvano predavanje

21.09.2001-27.09.2001

Split, Hrvatska

Povezanost rada

Biologija