Nalazite se na CroRIS probnoj okolini. Ovdje evidentirani podaci neće biti pohranjeni u Informacijskom sustavu znanosti RH. Ako je ovo greška, CroRIS produkcijskoj okolini moguće je pristupi putem poveznice www.croris.hr
izvor podataka: crosbi

Cognitive function improving in children with epilepsy switched from valproate to lamotrigine. (CROSBI ID 739970)

Prilog sa skupa u časopisu | izvorni znanstveni rad

Prpić, Igor ; Vlašić-Cicvarić, Inge ; Paučić-Kirinčić, Ela ; Korotaj, Zrinka ; Škarpa-Prpić, Ingrid Cognitive function improving in children with epilepsy switched from valproate to lamotrigine. // Epilepsia (Copenhagen). 2002. str. 184-x

Podaci o odgovornosti

Prpić, Igor ; Vlašić-Cicvarić, Inge ; Paučić-Kirinčić, Ela ; Korotaj, Zrinka ; Škarpa-Prpić, Ingrid

engleski

Cognitive function improving in children with epilepsy switched from valproate to lamotrigine.

PURPOSE: Anecdotal reports and rare studies in children revealed that lamotrigine (LTG) may have positive effect on cognitive functions. Therefore cognitive abilities in children with idiopathic generalised epilepsy (IGE) during treatment with valproate (VPA) and after they were switched to LTG were compared. METHODES: Fourteen children, 8 girls and 6 boys (M=13, 5 age ; SD 1.5) with newly diagnosed IGE (ILAE classification) were prospectively analysed. VPA was first AED in all children but due to its side effects children were switched to LTG mono-therapy. Average duration of VPA treatment was 24, 2 months. Average duration of LTG treatment was 10, 3 months. All children were seizure free on both treatments. Psychological assessment was performed during the VPA treatment and at least 6 months after the initiation of LTG (test-retest). Intellectual and cognitive abilities were evaluated by Perceptual Intelligence Test – Raven (PIT), the Bender-Gestalt Test (BGT) and Wechsler Intelligence Scales for Children (WISC). The Kaufman factors: Verbal Comprehension (VC), Perceptual Organisation (PO) and Freedom from Distractibility (FD) were calculated and compared (t-test, 2-sided) for test – retest examination. VC and PO are comparable to the WISC verbal and performance IQ and FD is an additional scale and reflects attention, concentration, memory and the ability of processing and sequencing. RESULTS: Mean Kaufman FD factor was 93, 6 (SD=16, 1) on children taking VPA and 102, 3 (SD=16, 4) on children taking LTG which was statistically significant difference (p=0.0003). There was not found significant differences comparing scores on VC, PO, PIT and BGT. CONCLUSION: All children after switching from VPA to LTG improved in attention, concentration, memory and the ability of sequencing and processing. Our results revealed that LTG have less impairment on specific cognitive functions in children with idiopathic generalised epilepsy. These data needs to be validated on greater number of children as well as in different types of epilepsy.

epilepsy; cognitive function; antiepileptic drugs

5th European Congress on Epileptology, October 6-10, 2002, Madrid, Spain.

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

nije evidentirano

Podaci o prilogu

184-x.

2002.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Epilepsia (Copenhagen)

0013-9580

Podaci o skupu

Nepoznat skup

ostalo

29.02.1904-29.02.2096

Povezanost rada

Kliničke medicinske znanosti

Indeksiranost