engleski

HLA Class I/NK Cell Receptor Interaction in Early Human Decidua basalis: Possible Functional Consequences

Human decidual NK (dNK) cells differ from their peripheral blood (PB)-NK counterparts. The major subset of PB-NK is CD56dim, CD16+, CD160+ (highly cytolytic), whereas the major sub-population of dNK is CD56bright, CD16- and CD160- (high cytokine producer). Extravillous cytotrophoblast invading the decidua basalis in early pregnancy express the polymorphic HLA-C, and non polymorphic HLA-E and HLA- G molecules that can interact with specific HLA class I-dependent dNK receptors, including the immunoglobulin-like KIRs, the lectin-like CD94/NKG2 and the CD160 receptors. There is no clear evidence thus far that dNK cells kill trophoblast cells. Instead they are able to secrete cytokines which are likely to be beneficial for the placental development, maternal uterine spiral arteries remodeling, and the anti- viral immune response.

Human decidual NK cells ; Pregnancy ; HLA-G molecules

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