engleski

Association of HLA-DRB1 alleles with severity of sarcoidosis

In the present study we investigated distribution of HLA-DRB1 alleles among 90 patients with sarcoidosis and 141 controls. All individuals were typed by PCR-SSP method. Analysis of DRB1 alleles showed significant differences for DRB1*11 and DRB1*0301 allele. DRB1*11 was significantly more frequent (p=0.0051) in patients with chronic onset of disease in comparison with controls, while higher frequency of DRB1*14 (7.0% vs. 4.3%) and lower frequency of DRB1*07 (3.5% vs. 9.6%) were marginally significant. In patients with acute onset of disease DRB1*0301 allele was significantly more frequent (p=0.0021). Among 36 patients with acute (erythema nodosum-EN) or chronic skin sarcoidosis DRB1*0301 allele was also present with statistically significant higher frequency (p=0.00004) compared with controls. However, patients with no-skin sarcoidosis (N=54) demonstrated higher frequency of DRB1*11 allele (p=0.026). Patients with chest X-ray stage I showed significantlly higher presence of DRB1*0301 allele (p=0.00064), while patients with chest X-ray stage II and III showed lower presence of DRB1*11 allele (p=0.0155) in comparison to control group. This study demonstrates that DRB1*11 positive patients have higher risk for chronic form of disease and II or III radiologic stage, while DRB1*0301 positive patients have higher risk for acute form of disease, radiologic stage I and EN.

HLA-DRB1; sarcoidosis

P61