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The role of ribosome biogenesis in cell growth and proliferation (CROSBI ID 509710)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa

Volarević, Siniša The role of ribosome biogenesis in cell growth and proliferation. 2002

Podaci o odgovornosti

Volarević, Siniša

engleski

The role of ribosome biogenesis in cell growth and proliferation

Cell growth and cell division are fundamental aspects of cell behavior in all organisms. Recent insights from many model organisms have shed light on the molecular mechanisms that control cell growth and cell division. A significant body of evidence has now been accumulated, showing a direct link between deregulation of components of cell cycle machinery and cancer. In addition, defects in one or more steps that control growth are important for malignant transformation, as many tumor suppressors and proto-oncogenes have been found to regulate cell growth. The importance of cell growth in tumor development is further supported by the discovery that rapamycin, an effective anticancer drug, inhibits a key regulator of protein synthetic machinery and cell growth, mammalian target of rapamycin (mTOR). In most cases, cell growth and cell division are coupled, thereby maintaining cell size within physiological limits. We believe that, in a long-term perspective, understanding how these two processes are coordinated in vivo and how their interplay is deregulated in a number of diseases, including cancer, may have a direct impact on the efficiency of modern therapeutics.

ribosome biogenesis; cell growth; cell proliferation

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Podaci o prilogu

2002.

nije evidentirano

objavljeno

Podaci o matičnoj publikaciji

Podaci o skupu

Croatian Congress on Molecular Life Sciences

pozvano predavanje

09.06.2002-13.06.2002

Opatija, Hrvatska

Povezanost rada

Biologija