Dopamine conjugate with styrene-maleic anhydride copolymer (CROSBI ID 468356)
Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija
Podaci o odgovornosti
Kalčić, Igor ; Zorc, Branka ; Butula, Ivan
engleski
Dopamine conjugate with styrene-maleic anhydride copolymer
Dopamine (3,4-dihydroxyphenethylamine, DOP) was covalently bond to styrene.maleic anhydride copolymer (SMA) in order to prepare polymeric prodrug SMA-DOP as potentially form of dopamine. The coupling reaction was run under nitrogen atmosphere in dry N, N-dimethylformamide in the presence of sodium dithionite. The remainig anhydride rings were opened with water. Shema The resulting conjugate contained 42.8 % of drug. Release of dopamine from SMA-DOP conjugate was studied in vitro and the following rate constants were obtained: k = 2.27 x 10-3 min-1 for pH = 7.4 and k = 7.98 x 10-2 min-1 for pH = 9.2.
dopamine; polymer-drug conjugate; kinetics
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Podaci o prilogu
109-x.
1996.
objavljeno
Podaci o matičnoj publikaciji
European Journal of Pharmaceutical Sciences (EUFEPS), Elsevier
Junginger, Hans E. ; Mulder, Gerard J.
Edinburgh: European Federation for Pharmaceutical Sciences
Podaci o skupu
Third European Congress of Pharmaceutical Sciences
poster
01.01.1996-01.01.1996
Edinburgh, Ujedinjeno Kraljevstvo