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Dopamine conjugate with styrene-maleic anhydride copolymer (CROSBI ID 468356)

Prilog sa skupa u zborniku | sažetak izlaganja sa skupa | međunarodna recenzija

Kalčić, Igor ; Zorc, Branka ; Butula, Ivan Dopamine conjugate with styrene-maleic anhydride copolymer // European Journal of Pharmaceutical Sciences (EUFEPS), Elsevier / Junginger, Hans E. ; Mulder, Gerard J. (ur.). Edinburgh: European Federation for Pharmaceutical Sciences, 1996. str. 109-x

Podaci o odgovornosti

Kalčić, Igor ; Zorc, Branka ; Butula, Ivan

engleski

Dopamine conjugate with styrene-maleic anhydride copolymer

Dopamine (3,4-dihydroxyphenethylamine, DOP) was covalently bond to styrene.maleic anhydride copolymer (SMA) in order to prepare polymeric prodrug SMA-DOP as potentially form of dopamine. The coupling reaction was run under nitrogen atmosphere in dry N, N-dimethylformamide in the presence of sodium dithionite. The remainig anhydride rings were opened with water. Shema The resulting conjugate contained 42.8 % of drug. Release of dopamine from SMA-DOP conjugate was studied in vitro and the following rate constants were obtained: k = 2.27 x 10-3 min-1 for pH = 7.4 and k = 7.98 x 10-2 min-1 for pH = 9.2.

dopamine; polymer-drug conjugate; kinetics

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Podaci o prilogu

109-x.

1996.

objavljeno

Podaci o matičnoj publikaciji

European Journal of Pharmaceutical Sciences (EUFEPS), Elsevier

Junginger, Hans E. ; Mulder, Gerard J.

Edinburgh: European Federation for Pharmaceutical Sciences

Podaci o skupu

Third European Congress of Pharmaceutical Sciences

poster

01.01.1996-01.01.1996

Edinburgh, Ujedinjeno Kraljevstvo

Povezanost rada

Kemija