engleski

FIBROMUSCULAR DYSPLASIA OF RENAL ARTERIES IN NON- TUMOROUS SURGICAL SPECIMENS

INTRODUCTION AND AIM: Arterial fibromuscular dysplasia (FMD) is a condition that most frequently involves renal arteries, and is bilateral in nearly half of the cases. It is more frequent on the right side (3:1), with female predominance. FMD of the renal arteries usually involves distal parts of the artery and its branches. The aim of this study was to analyze renal arteries in patients who underwent nephrectomy due to non-tumorous conditions of the kidney. MATERIALS AND METHODS: We analyzed a consecutive series of 30 patients (m:f=14:16) who underwent nephrectomy in the year 2003, and whose histopathologic examination resulted in diagnosis of a benign condition. Eight patients were excluded from the study because specimens of renal arteries were not found. The median age of the patients (m:f=8:14) was 59.4 years (range 39-78 y). The patients were divided into the group showing FMD (group I) and those that showed no pathological changes of the renal arteries (group II). Specimens were routinely fixed, embedded in paraffin, cut at 5 μ m, stained with hematoxylin and eosin, and examined by light microscopy. RESULTS: FMD of the renal arteries (group I) was found in 10/22 patients (m:f=4:6) , with median age of 64 y (range 39-79 y). Renal arteries in 12/22 patients (group II) (m:f=4:8), with median age of 61 y (range 43-70 y), showed no changes. Histopathologic analysis of the renal tissue showed chronic pyelonephritis in all 10 patients from the group I, while 7 patients from the group II had the same diagnosis. Other diagnoses in the group II were renal calculi, cystic renal disease, hydronephrosis and renal hypoplasia. CONCLUSION: In other studies, the incidence of FMD in renal arteries, found at autopsy was about 1%, but we did not find any data about the incidence in vivo. In this study, fibromuscular dysplasia of the renal arteries was observed in a significant proportion of patients who underwent nephrectomy due to non-tumorous diseases. The significance of this finding should be further analyzed.

Fibromuscular dysplasia; Renal arteries

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